Leishmania Donovan! 



567 



others, and its developmental forms observed, it was agreed 

 that it belonged in a new genus of micro-organisms, not far 



* % f 9 



% ! - 



, .fl 



V- '* 



f 



A* 



rSi^- 







Fig. 195. Evolution of the parasite of kala-azar: i to 5. Parasites 

 of kala-azar. i, Isolated parasites of different forms in the spleen and 

 liver; 2, division forms from liver and bone-marrow; 3, mononuclear 

 spleen cells containing the parasites; 4, group of parasites; 5, phagocy- 

 tosis of a parasite by a polynuclear leukocyte. 6 to 15. Parasites from 

 cultures. 6, First changes in the parasites. The protoplasm has in- 

 creased in bulk and the nucleus has become larger; 7, further increase 

 in size; vacuolization of the protoplasm; 8, division of the enlarged 

 parasite; 9, evolution of the flagella; 10, small piriform parasite show- 

 ing flagellum; n, further development and division of the parasite; 12, 

 flagellated trypanosoma-like form; 13, 14, flagellated forms dividing by 

 a splitting off of a portion of the protoplasm; 15, narrow flagellated 

 parasites which have arisen by the type of division shown in 13 and 14. 

 (From Mense's " Handbuch," after Leishman.) 



removed from the trypanosomes, and eventually Ross, and 

 then Laveran and Mesnil, honored both of its discoverers by 



