Histoplasmosis 575 



blood- and lymph-vessels and capillaries, and by the infec- 

 tion of distant regions by the dislodgment of infected endo- 

 thelial cells and their transportation thither by the blood- and 

 lymph -stream. Thus the skin, intestinal, and pulmonary 

 nodules may be due to secondary distribution of the parasite. 

 The micro-organism apparently lives for a considerable 

 period of time iin the tissues, because in the older areas of 

 necrosis there are myriads of parasites all staining well. 



The mode of infection and portal of entry are unknown. 

 The parasite has neither been cultivated nor transmitted by 

 inoculation. 



Believing it to be a new parasite, Darling has suggested 

 that it be called Histoplasma capsulatum. 



