CHAPTER XXII 



YELLOW FEVER. 



THE bacteriology of yellow fever has been studied by 

 Domingos Freire,* Carmona y Valle,f Sternberg,J Havel- 

 burg^ and Sanarelli,|| but all of their work has been shown 

 to be incorrect by the interesting researches and very con- 

 clusive results of Finlay,** Carter, ff Reed, Carroll, Lazear, 

 and Agramonte, J { and Reed and Carroll, which have 

 proved the mosquito to be the definitive host of an invis- 

 ible micro-organism. 



Reed, Carroll, Lazear, and Agramonte, |||| constituting a 

 Board of Medical Officers "for the purpose of pursuing scien- 

 tific investigations with reference to the acute infectious dis- 

 eases prevalent on the island of Cuba," began their work in 

 1900, at Havana, by a careful investigation of the relationship 

 of Bacillus icteroides to yellow fever. By a most careful tech- 

 nic they withdrew and examined the blood from the veins of 

 the elbow of 1 8 cases of yellow fever, making 48 separate ex- 

 aminations on different days of the disease, and preparing 

 115 bouillon cultures and 18 agar plates, every examination 

 being negative so far as Bacillus icteroides was concerned. 



*" Doctrine microbienne de la fievre jaune et ses inoculation pre- 

 ventives," Rio Janeiro, 1885. 



f "Lemons sur 1'etiologie et la prophylaxie de la fievre jaune," Mexico, 

 1885. 



t "Report on the Etiology and Prevention of Yellow Fever," Wash- 

 ington, 1891; "Report on the Prevention of Yellow Fever by Inocula- 

 tion," Washington, 1888. 



"Ann. de 1'Inst. Pasteur," 1897. 



|| "Brit. Med. Jour.," July 3, 1897; "Ann. de 1'Inst. Pasteur," 

 June, Sept., and Oct., 1897. 



** "Amer. Jour. Med. Sci.," 1891, vol. en, p. 264; "Ann. de la Real 

 Academia," vol. xvm, 1881, pp. 147-169; "Jour. Amer. Med. Assoc.," 

 vol. xxxvm, April 19, 1902, p. 993. 



ft "New Orleans Med. Jour.," May, 1890. 



U "Phila. Med. Jour.," Oct. 27, 1900; "Public Health," vol. xxvi, 

 1900, p. 23. 



"Public Health," vol. xxvn, 1901, p. 113. 



Ill) "Phila. Med. Jour.," Oct. 27, 1900. 



576 



