7 8 2 



Glanders 



acute form is quickly fatal, death sometimes coming on in 

 from four to six weeks ; the chronic form may last for several 

 years and end in complete recovery. 



Lesions. When stained in sections of tissue the bacilli 

 are found in small inflammatory areas. These nodules can 

 be seen with the naked eye scattered through the liver, 

 kidney, and spleen of animals dead of experimental glanders. 

 They consist principally of leukocytes, but also contain 

 numerous epithelioid cells. As is the case with tubercles, 



Fig- 255. Pustular eruption of acute glanders as exhibited on the day 

 of the patient's death, twenty-eight days after initial chill (Zeit). 



the centers of the nodules are prone to necrotic changes, but 

 the cells show marked karyorrhexis, and the tendency is more 

 toward colliquation than caseation. The typical ulcera- 

 tions depend upon retrogressive changes occurring upon 

 mucous surfaces, the breaking down of the nodules per- 

 mitting the softened material to escape. At times the 

 lesions heal with the formation of stellate scars. 



Baumgarten* regarded the histologic lesions of glanders 

 as much like those of the tubercle. He first saw epithe- 

 * " Pathologische Mykologie," Braunschweig, 1890. 



