Pathogenesis 783 



lioid cells accumulate, followed by the invasion of leuko- 

 cytes. Tedeschi* was not able to confirm Baumgarten's 

 work, but found the primary change to be necrosis of the 

 affected tissue followed by invasion of leukocytes. The 

 observations of Wright | are in accord with those of Tedeschi. 

 He first saw a marked degeneration of the tissue, and then 

 an inflammatory exudation, amounting in some cases to 

 actual suppuration. 



Glanders in Human Beings. Human beings are but 

 rarely infected. The disease has, however, occurred among 



Fig. 256. Farcy affecting the skin of the shoulder (Mohler and 

 Eichhorn, in Twenty-seventh Annual Report of the Bureau of Animal 

 Industry, U. S. Department of Agriculture, 1910). 



those in frequent contact with many horses and among 

 bacteriologists. It occurs either in an acute form in which, 

 from whatever primary focus may have been its starting- 

 point, the distribution of micro-organisms may be so rapid 

 as to induce an affection with skin lesions resembling small- 

 pox and terminating fatally in eight or ten days. 



The chronic form in man is chiefly confined to the nasal 

 and laryngeal mucosa. It is commonly mistaken for more 

 simple infections, and though it sometimes shows its character 

 by generalizing, it not infrequently recovers. 



* "Ziegler's Beitrage z. path. Anat.," Bd. xm, 1893. 



t "Journal of Experimental Medicine," vol. I, No. 4, p. 577. 



