7 8 4 



Glanders 



Virulence. The organism is said to lose virulence if 

 cultivated for many generations upon artificial media. 

 While this is true, attempts to attenuate fresh cultures by 

 heat, etc., have usually failed. 



Immunity. Leo has pointed out that white rats, which 

 are immune to the disease, may be made susceptible by 

 feeding with phloridzin and causing glycosuria. 



Babes has asserted that the injection of mallein into sus- 

 ceptible animals will immunize them against glanders. 

 Some observers claim to have seen good therapeutic results 



I 



Fig. 257. Lesions of glanders in the nasal septum of a horse (Mohler 

 and Eichhorn, in Twenty-seventh Annual Report of t the Bureau of 

 Animal Industry, U. S. Department of Agriculture, 1910). 



follow the repeated injection of mallein in small doses. 

 Others, as Chenot and Picq,* find blood-serum from im- 

 mune animals like the ox to be curative when injected 

 into guinea-pigs infected with glanders. 



Pseudoglanders Bacillus. A bacillus similar in its tinc- 

 torial and cultural peculiarities, but not pathogenic for mice, 

 guinea-pigs, or rabbits, was isolated from pus by Selter. f The 

 organism was called the pseudoglanders bacillus. A similar 

 one had previously been described by JJabes.f 



* " Compte-rendu de la Soc. de Biol.," March 26, 1892. 



t "Centralbl. f. Bakt.," etc., Feb. 18, 1902, xxxv, 5, p. 529. 



I "Archiv. de med. exp. et d'anat. path.," 1891. 



