786 Rhinoscleroma 



resemble those of the bacillus of Friedlander (q. v.) so closely 

 as to be indistinguishable from it. Even when inoculated 

 into animals the bacillus behaves much like Friedlander 's 

 bacillus. 



Inoculation has, so far, failed to reproduce the disease 

 either in man or in the lower animals. 



,%! 



Fig. 258. Bacillus rhinoscleromatis. Pure culture on glycerin agar- 

 agar. Magnified 1000 diameters (Migula). 



Pathogenesis. The bacillus is said to be pathogenic for 

 man only, producing granulomatous formations of the skin 

 and mucous membranes of the anterior and posterior nares. 

 These vary in structure according to age. The young nodes 

 consist of a loose fibrillar tissue composed of lymphocytes, 

 fibroblasts, and fibers. Some of the cells are large and have a 

 clear cytoplasm and are known as the cells of Mikulicz. In 

 and between them the bacilli are found in considerable num- 

 bers. The older lesions consist of a firm sclerotic cicatricial 

 tissue. 



