CUTANEOUS AND INTERNAL SENSATIONS. 273 



of water, however, must affect the water content of all the tissues, 

 and under these conditions sensations are experienced whose quality 

 is not that of simple thirst alone, but of pain or suffering. All ac- 

 counts agree that complete deprivation of water for long periods 

 induces intense discomfort, anguish, and possibly mental troubles, 

 and we may suppose that under these conditions sensory nerves 

 are stimulated in many tissues, and that the metabolism in the ner- 

 vous system in addition is directly affected by the loss of water. 

 It is interesting to note that/ while in diseases due to a general in- 

 fection, loss of appetite, anorexia, is a frequent symptom, there is 

 no corresponding loss of the sense of thirst. Even in hydrophobia 

 the patient experiences the sensations of thirst, although unable to 

 drink water. 



18 



