30 BACILLUS ANTHRACIS 



susceptible animal, and are distributed in a passive 

 manner, being themselves immobile, by the blood 

 stream. The appearances presented in sections are 

 conditioned by these circumstances. In man sub- 

 cutaneous inoculation gives rise to a distinct local 

 lesion, the " Malignant Pustule." This appears as a 

 small vesicle seated on an indurated base. The 

 centre rapidly becomes black and gangrenous, and 

 the eschar is surrounded by other vesicles which 

 unite with one another and with the primary lesion. 

 There is great swelling and oedema of the tissues. 

 A section through such a malignant pustule is 

 shown in Fig. 20. The centre of the eschar is im- 

 mediately to the right of that portion of the pustule 

 which is shown. It will be seen that the papillae 

 are distended and disintegrated by the oedema, 

 while they are at the same time crowded with 

 bacilli, which also extend for some distance into the 

 subcutaneous tissue. In the papillae, as is best seen 

 in the one at the right of the section, the bacilli are 

 arranged in the direction of the blood-vessels. 



In the lung, as represented in Fig. 21, the 

 alveolar wall is but little modified, and the alveoli 

 are free from inflammatory deposits, but the capil- 

 laries are filled by bacilli, and the alveoli are mapped 

 out by this bacillary injection. 



