PLASMODIUM MALARLE 105 



ance in the corpuscle (Fig. 109). The nucleolus and 

 nucleus gradually become less distinct, and are un- 

 distinguishable at the time of sporulation. 



The above description applies to the intra-corporeal 

 phase of the parasite, and these forms are destroyed 

 or disappear on the administration of quinine. In 

 the blood of patients suffering from the so-called 

 malignant fevers, another form the crescent body 

 is also found (Fig. 110). These are very regular, 

 intra-corpuscular, crescent-shaped organisms, con- 

 taining pigment which is usually, but not invariably, 

 placed centrally ; a very delicate convex line repre- 

 senting the red corpuscle passes from horn to horn 

 of the crescent on its concave side. The crescent 

 is thought by Mannaberg to be a syzigium formed 

 by the conjugation of two plasmodia in a doubly 

 infected corpuscle. 



In blood which has been shed for some time 

 10 to 30 minutes and especially in blood which has 

 been exposed to air and slight moisture, "flagellated 

 bodies" are found (Fig. 111). These flagellated bodies 

 are free, pigmented, protoplasmic masses resembling 

 fully developed parasites from whose periphery 

 start actively motile filaments (flagella) which break 

 away, become free, and rapidly move about among 

 the blood cells. The remains of the body from 



