SYMPTOMATIC ANTHRAX. 283 



different characters in the blood, in the tumors 

 among the muscles, and in the effused serum in 

 the connective tissue. 



Immunity is said to result from intra-venous 

 injection of material containing the microbe. 

 Subsequent sub-cutaneous injection of pulp from 

 a tumor produces no results in these animals. 

 The value of this method has been tested by ex- 

 periments upon 244 animals, made under the 

 authority of the French Government. The re- 

 sults of intra-venous injection differ with the 

 amount of virus employed. When the quantity 

 is very small, general disturbances are produced 

 which disappear in two or three days, leaving the 

 subject immune. When the dose is considerable, 

 fatal symptomatic anthrax is produced. The ex- 

 perimenters suppose that in non-fatal intra-venous 

 injections the bacterium multiplies in the blood, 

 but is prevented by the endothelium of the vessels 

 from entering the connective tissue. 



Filtration experiments show that the poison is 

 particulate, and the authors quoted claim to have 

 proved that the bacterium described by them is 

 the veritable cause of the disease. The experi- 

 ments recently made by the same authors to de- 

 termine the comparative value of disinfectants 

 for the destruction of this virus,, seem to support 

 their deductions as to the essential etiological role 

 of the microbe. 



The preservation of virulence after exposure 

 to sulphurous acid, to alcohol saturated with cam- 



