INTERMITTENT FEVER. 321 



sisted of culture-experiments with organisms found in 

 malarial and other soils, of experiments on animals, and 

 culture-experiments with quinine. They resulted in 

 proving that the spores could be cultivated, Ceri 

 applying the term natural germs to those found in the 

 atmosphere and soil, and artificial germs to those which 

 result from their culture ; that animals could be infected 

 by their injection into the blood, though to a less degree 

 by the cultivated than by the natural germs, the former 

 growing weaker in successive generations ; and that 

 the infecting properties could be retarded by the appli- 

 cation of heat to culture-fluids, and the introduction of 

 quinine into them, certain degrees of the former and 

 strengths (1 : 800) of the latter making the culture 

 of the spores impossible, and arresting the putrid fer- 

 mentation induced by them. The practical application 

 of these facts is self-evident. 



" Finally the opportunity has recently been present- 

 ed to Dr. Franz Ziehl to test these results clinically l 

 in three typical cases of malaria, in all of which the 

 spleen was enlarged. In all three the bacilli above de- 

 scribed were found in the blood taken from any part of 

 the body by the prick of a needle, and examined in the 

 fresh state, or dried in a thin layer upon a cover-glass, 

 by simply passing the latter over a flame. These have 

 been preserved by Dr. Ziehl for three months without 

 undergoing any change. 



44 The bacilli thus observed were of different lengths, 

 but usually were from one-fourth to the entire diameter 

 of a red corpuscle. The majority of those measured 

 were about 4 micro-millimetres long and .7 broad. Their 

 ends were swollen and roundish." 



The evidence as here stated certainly seems very 



1 Deutsche medizinische Wochenschrift, Nov. 25, 1882. 

 21 



