INTERMITTENT FEVER. 327 



that, if a dose of ten grains passed at once into 

 the blood of an adult weighing one hundred and 

 sixty pounds, the proportion which it would bear 

 to the whole mass of blood in the body (estimated 

 at twenty pounds) would be only 1 : 11,520; whereas 

 Professor Ceri's experiments lead him to the con- 

 clusion, " that the muriate of quinine in the pro- 

 portion of 1 : 800 prevents the development of any 

 infectious germs." 1 



The preventive power for the Bacillus maZartce, 

 however, was found to be greater than this, and in 

 a series of eighteen experiments in which culture- 

 solutions were infected " with a drop of blood [con- 

 taining the Bacillus malarias] of a rabbit into which 

 had been injected cultures of malarial soil, the 

 development continued absent up to 1 : 2,000, and 

 at 1 : 2.250 it was aseptic. The Bacillus malarias 

 did not develop in the fertile cultures, which con- 

 tained only vibriones." 



The writer is not disposed to underestimate the 

 value of these researches, but in a spirit of scien- 

 tific conservatism would remark as follows : 



First. Fowler's solution of arsenic also cures 

 intermittent fever; and the germicide power of 

 this remedy is practically nil, as determined by the 

 writer in a series of experiments in which the 

 micrococcus of pus served as a test-organism. In 

 the proportion of forty per cent it failed to kill 

 this organism. Its power of restricting the devel- 



1 Quoted from translation by Hugo Engel in " The Medical Times," 

 Philadelphia, Dec. 16, 1882, p. 198. 



