354 BACTERIA IN INFECTIOUS DISEASES. 



been able to obtain any certain evidence as to whether 

 they move or not. Their relation to the white blood 

 corpuscles is peculiar. They penetrate these, and mul- 

 tiply in their interior. One often finds that there is 

 hardly a single white corpuscle in the interior of which 

 bacilli cannot be seen. Many corpuscles contain isolated 

 bacilli only ; others have thick masses in their interior, 

 the nucleus being still recognizable ; while in others the 

 nucleus can be no longer distinguished ; and finally 

 the corpuscle may become a cluster of bacilli, breaking 

 up at the margin, the origin of which one could not 

 have explained had there been no opportunity of seeing 

 all the intermediate steps between the intact white 

 corpuscle and these masses (Fig. 19). Starting from 

 the point of inoculation, one can easily see the path by 

 which the bacilli have penetrated into the body. In the 

 subcutaneous cellular tissue in the neighborhood of the 

 inoculated spot they are very numerous, and at times 

 accumulated in dense masses, as can be best observed 

 in inoculations on the ear. ... I have never found 

 these bacilli in the lymphatic vessels. ... I have not 

 found them free in the cavities of the body. ... In 

 the capillaries the bacilli congregate, particularly at the 

 points of division ; but I have never yet seen a complete 

 obstruction of the smaller vessels produced in this way. 

 ... In exactly the same manner are the bacilli dis- 

 tributed in the rest of the vascular system. In the ex- 

 amination of sections of lung, liver, kidney, and spleen, 

 one meets everywhere with vessels containing free 

 bacilli, and with white blood corpuscles with bacilli in 

 their interior. . . . The whole morbid process has thus 

 a great resemblance to anthrax. In both diseases the 

 infective power of the blood is due to the bacilli present 

 in it ; as soon as these disappear, the disease can be no 

 longer produced by inoculation with the blood. Both 



