BACTERIA IN INFECTIOUS DISEASES. 245 



is not the case. We cannot, then, believe that during 

 the life of the parasite certain substances are produced 

 which are capable of arresting its ulterior develop- 

 ment." (Comptes rendus Acad. des &?., XC. pp. 952- 

 958.) 



It is a little surprising that after disproving, by 

 the experimental method, the hypothesis last men- 

 tioned, which had been proposed by a member of 

 the French Academy in explanation of the phe- 

 nomenon in question, Pasteur did not, in accord- 

 ance with his usual custom, attempt to establish 

 his own hypothesis upon a firm foundation by an 

 experiment which at once suggests itself. If a 

 fowl which is protected against cholera, or an 

 animal which is protected against anthrax, owes 

 this protection to the fact that a certain material 

 which is required for the development of the 

 microbe of fowl-cholera, or for the anthrax bacil- 

 lus, has been exhausted in the course of the modi- 

 fied form of the disease to which immunity is due, 

 then the flesh of such an animal, made into bouillon, 

 should not constitute a proper culture-medium for 

 the organisms in question. The writer ventures 

 to predict that the result of such an experiment 

 would not be favorable to Pasteur's hypothesis, 

 and that it will be found that the micrococcus of 

 fowl-cholera can be cultivated in bouillon made from 

 the flesh of a protected animal, and that the bacil- 

 lus of anthrax may multiply freely in the blood, or 

 in an infusion of the flesh, of an animal which, 

 before it was killed for the experiment, possessed 



