308 BACTERIA IN INFECTIOUS DISEASES. 



animals commonly used in experimental studies 

 of this nature are not susceptible to inoculations 

 in the urethra, the vagina, or the conjunct! val 

 sac, with the most virulent gonorrhoeal pus. This 

 fact is established by the experiments of several 

 independent observers, and has been verified by 

 the writer as regards the dog, the rabbit, and the 

 guinea-pig. 



" Konigstein has made frequent inoculation experi- 

 ments with the secretions of blenorrhoea neonatorum. 

 This was smeared into the eyes of dogs and rabbits; 

 and in some cases after so doing the eye was sewn up. 

 Here all results were negative, even those made on 

 puppies which were still sucking. In speaking of the 

 microscopic examination of the secretions, Konigstein 

 confirms Neisser's discovery, but does not agree ivith him 

 in considering the diplococci as characteristic of a gonor- 

 rhoeal inflammation of a mucous membrane." (Quoted 

 from Keyser, italics by writer.) 



Eklund also finds that the "gonococci" of Neisser 

 are uniformly present, but he decidedly rejects the 

 opinion that they constitute in an exclusive sense 

 the microbes of blennorrhagia, since he has dis- 

 covered organisms precisely similar in cases of 

 acute and chronic ulceration of the bowels and 

 lungs, and also of ulcerative stomatitis. In fact, 

 he regards these gonococci (to use his own ex- 

 pression) as a sort of pathological " sappers and 

 miners." But Dr. Eklund has also discovered in 

 pus and the superficial exudations of the inflamed 

 urethral mucous membrane an entirely new spe- 



