GONORRHOEA. 313 



in the same manner into the urethra of J. D., subject of 

 previous experiment. Result negative. 



" Exp. No. 6 (August, 1883). A fresh culture, thir- 

 teenth, was introduced into the urethra of W. B. 

 Result negative. . . . 



" Exp. No. 15 (October 5th, 1882). A pure culture 

 of the micrococcus of gonorrhceal pus (the thirtieth cul- 

 ture, or above), was introduced into the urethras of two 

 healthy men [G. M. S. and Y. D.], by means of 

 pledgets of cotton wool soaked in the fluid, which were 

 left in situ for fifteen minutes. Result entirely nega- 

 tive." 



A somewhat extended account has been given 

 of these experiments relating to the etiology of 

 gonorrhoea, because it is deemed a matter of great 

 scientific importance to determine, in a definite 

 manner, the relation of the micrococcus, demon- 

 strated to be constantly present, to the infective 

 virulence of the material containing it. It is evi- 

 dent that if a single infectious disease is shown to 

 be independent of all micro-organisms, no general- 

 ization in favor of the parasitic-germ theory will be 

 possible, and the etiology of each infectious disease 

 must be worked out separately by the experimental 

 method. 



In the disease under consideration, it is evident 

 that the contradictory results reported call for 

 farther investigation ; and, notwithstanding the 

 negative results which have attended his own 

 experimental inoculations, and the fact that the 

 " ffonococew " of Neisser has not distinctive mor- 

 phological characters, the writer will be very ready 



