370 BACTERIA IN INFECTIOUS DISEASES. 



neighborhood of the place of injection, not a trace of 

 pus could be observed. On the other hand, slight oedema, 

 with a streaky whitish appearance of the subcutaneous 

 cellular tissue, extended from the point of injection to 

 the abdomen. In this cedematous cellular tissue lay 

 numerous flat extravasations of blood half a centimeter 

 in breadth, the vessels around being greatly distended. 

 The muscles of the thigh and of the abdominal walls 

 were also interspersed with small extravasations. [These 

 hemorrhagic extravasations were common also in the 

 victims of the writer's experiments.] In the heart and 

 lungs no alterations were found. In the peritoneal 

 cavity no fluid was present, the peritoneum being un- 

 altered and the coils of intestine not glued together. 

 But the surface of the intestine, in consequence of a 

 number of small subserous extravasations, presented an 

 appearance as if injected here and there with blood. 

 The spleen was also very considerably enlarged. In 

 this second animal the oval micrococci were alone present 

 in the cedematous cellular tissue, all the other bacteria 

 having disappeared. The number of these organisms 

 was very considerable, many of the small veins being 

 completely filled with them. . . . 



" These micrococci differ from the micrococci of 

 pysemia very markedly as regards size, and in most 

 other points. Thus they never enclose the blood cor- 

 puscles, even when they have accumulated in large 

 numbers in the interior of the blood-vessels. They 

 rather push them on one side. They do not cause co- 

 agulation of the blood, and thus emboli do not occur." 



The experiments made by the writer have been 

 repeated by Claxton, who says : 



" I shall now discuss briefly the second part of my 

 argument, namely, what constituent of the saliva pro- 



