404 BACTERIA IN INFECTIOUS DISEASES. 



in many of his experiments. Letzerich also seems 

 to have been ignorant of the fact that the sputum 

 of healthy persons produces septicaemia in rabbits, 

 and his inference that rabbits inoculated with the 

 sputum of a fever patient suffered an attack of 

 genuine typhoid, is probably as wide of the mark as 

 was Pasteur's with reference to the " new disease " 

 described by him as resulting from inoculating 

 rabbits with the saliva of a child dead of hydro- 

 phobia. One of Letzerich's rabbits died at the 

 end of five days, and one was killed at the end of 

 twelve days. Micrococci and rods were found in 

 the spleen, in the veins, and in the follicles of the 

 intestine, but the evidence presented in favor of 

 the view that these animals had typhoid fever is 

 entirely unsatisfactory. 



Brantlecht produced in young rabbits most of 

 the typhoid symptoms by the subcutaneous injec- 

 tion of culture-liquids ; but he obtained the same 

 results with bacilli found during the summer months 

 in the water of stagnant ponds (Cameron). Chorn- 

 jakoff, a pupil of Klebs, injected typhoid ba- 

 cilli (?) into the peritoneum of rabbits. The 

 animals immediately exhibited an elevation of 

 temperature, which attained its maximum on the 

 third day. They all died on the third or fourth 

 day, in two instances with diarrhoea. The lesions 

 were, redness and tumefaction of Peyer's glands, 

 increase in volume of the spleen, cellular infiltra- 

 tion of the intestinal tissues. The presence of 

 micrococci was doubtful, but the peritonitis was in 



