TYPHOID FEVER. 



407 



These were found in the typhoid ulcers, and con- 

 sisted of masses of inicrococci. Klein also found 

 groups of micro- 

 cocci in the mucous 

 membrane, in the 

 lymph follicles, and 

 in the spleen. Fische 

 found colonies of 

 micrococci in the 

 spleen and in the 

 lymphatic glands in 

 fifteen out of twenty- 

 nine cases exam- 

 ined. The positive 

 results were mostly 

 obtained in recent 

 cases; some of these, 

 however, gave a negative result. Klebs found 

 organisms micrococci or bacilli in twenty-four 

 cases examined by him. Koch found bacteria in 

 half the cases which he examined ; Meyer in 

 eighteen out of twenty-four; and Eberth in 

 eighteen out of forty. Eberth remarks that the 

 result would probably have been more favorable 

 but for the fact that the organism in many cases 

 seems to have been destroyed in the tissues. In 

 the negative cases the height of the fever was 

 already past. The bacilli are said to be most nu- 

 merous during the first twelve or fourteen days of 

 sickness, less numerous at the end of the third 

 week, and they were seldom met with in the fifth 



Fig. 24. 



From a fresh section of typhoid intestine ; treated 

 with glacial acetic acid and glycerine mixture. 

 Siebert's im. No. 7, Ocular 3 Klebs). 



