POISONS AND THEIR PREVENTION 215 



toxin were used for the cerebral inoculations, the 

 animals survived the otherwise fatal doses they 

 had received of the toxin ; whilst out of seventeen 

 guinea-pigs which received subcutaneous inocula- 

 tions of the anti-toxin only two recovered, and 

 the quantity of the anti-toxin employed reached 

 as much as from ten to twenty cubic centimetres 

 in some of the experiments, contrasting in a re- 

 markable manner with the few drops which sufficed 

 in the case of the cerebral inoculations. 



Dr. Roux sums up this splendid result in the 

 following modest words : " II ne suffit pas de 

 donner de 1'anti-toxine, il faut la mettre au bon 

 endroit." 



The significance and far-reaching application 

 of this most important discovery cannot easily be 

 overestimated. Hitherto the preparation of an 

 anti-toxin has been the chief point considered, 

 but Dr. Roux and his able coadjutor, M. A. Borrel, 

 have shown how great may be the results which 

 attend its method of administration, and have 

 opened up an entirely new direction for investiga- 

 tion. 



Although the subject of immunity is not, as 

 we have seen, by any means wholly a latter-day 

 creation, yet its approach and consideration from 

 a modern point of view, assisted by the resources 

 and equipment- provided by modern scientific 



