CONTENTS. xix 



PAGE 



. 458. The corresponding changes in the mammal 754 



459. The nature and meaning of these changes 755 



460. Views as to the manner in which glycogen is stored in the hepatic 



cells. By simple dehydration of sugar 756 



461. The glycogen formed by a product of the metabolism of the hepatic 



cells. Comparison of the two views 757 



462. The uses of glycogen. The formation of fat as a store of carbon- 

 holding material . . 760 



463. Glycogen in muscle 763 



464. Glycogen in the placenta and in various tissues .... 764 



Diabetes. 



465. Natural diabetes. Artificial diabetes 764 



466. The nerves of the liver 766 



467. The nervous mechanism of the diabetic puncture .... 766 

 468. Pancreatic diabetes. The diminution of hepatic glycogen by arsenic 



and other agents 768 



SECTION III. 

 THE SPLEEN. 



469. The general structure of the spleen 771 



470. The reticulum of the spleen 772 



471. The blood vessels of the spleen and their relation to the reticulum . 773 



472. The lymphatics of the spleen. The Malpighian corpuscles . . 774 



473. The nerves of the spleen 775 



474. The spleen pulp ; the white and red corpuscles. Changes undergone 



by the latter 775 



475. The movements of the spleen. The spleen curve .... 776 



476. The chemical constituents of the spleen 779 



SECTION IV. 

 THE. FORMATION OF THE CONSTITUENTS OF BILE. 



477. The formation of bilirubin from haemoglobin 780 



478. The nature of and preparations towards this formation . . . 782 



479. The formation of bile acids 782 



480. The relations of the secretion of bilirubin to the secretion of bile 



acids 783 



481. The relation of the secretion of bile to the formation of glycogen . 784 



SECTION V. 

 ON UREA AND ON NITROGENOUS METABOLISM IN GENERAL. 



482. Urea the end-product of the metabolism of proteid matter . . 785 



483. Urea probably the result of a series of changes .... 786 



484. The kreatin of muscle in its relations to urea 786 



485. Difficulties presented by the normal presence of kreatin in urine . 787 



486. The nitrogenous metabolism of the nervous tissues .... 788 



