PATHOGENIC BACTERIA. 123 



distinguished from the gonococcus, in that they are colored with 

 Gram's method, whereas the micrococcus of gonorrhoea is not. 

 Therefore it is always necessary, after having first found these 

 peculiar-shaped microbes, to apply Gram's stain, and if they are 

 then not found one can safely say it is the gonococcus. 



Pathogenesis. The attempts to infect the experiment ani- 

 mals with gonorrhoea have so far been without success. In man, 

 upon a healthy urethra, a specific urethritis was produced with 

 even the 20th generation of the culture. Gonorrhoeal ophthalmia 

 contains the cocci in great numbers, and gonorrhoeal rheumatism 

 is said to be caused by the lodgment of the cocci in the joints. 



The microbes have been found long after the acute attack, 

 when only a very slight oozing remained, and the same were 

 very virulent. 



The specific inflammations of the generative organs of the 

 female are due to this microbe extending its influence, having 

 gained entrance through the vagina. It is found chiefly in the 

 superficial layers of the mucous membrane. 



Similar Microbes found in the Urethra and Vagina. 



Micrococcus Citreus Conglomerates. (Bumm.) Very similar 

 to the gonococci in form, they are, however, easily cultivated, 

 and form yellow colonies which dissolve the gelatine and grow 

 quite rapidly \ the surface of the gelatine is at first moist and 

 shiny, but later on wrinkled. They are colored with Gram's 

 method, and have no special pathological action. They are found 

 in the air and gonorrhoeal pus. 



Diplococcus Albicans Amplus. (Bumm. ) In vaginal secretion. 

 The diplococci are much larger than the gonococci, but similar 

 in form. They are also cultivated upon gelatine plates, grayish- 

 white colonies, which slowly liquefy gelatine. They grow mode- 

 rately rapid. Stained with Gram's method, and have no 

 pathogenic action. 



Diplococcus Albicans Tardissimus. (Bumm.) 



Origin. In urethral pus. 



Form. Like gonococci. 



Properties. Im motile ; do not liquefy gelatine. 



Growth. Very slow at ordinary temperature, but more rapid 



