loO ESSENTIALS OF BACTERIOLOGY. 



fering from this disease become attacked with the fever, and in 

 their blood the spirillum is again found. It is found in the 

 blood, only in the relapses (during the fever). After the attack 

 the spirilla gather in the spleen and gradually die there. It 

 has been found in the brain, spleen, liver, and kidneys. In the 

 secretions it has not been discovered. 



Bacillus Malariae. (Klebs and Tommaci-Crudcli.) 



Origin. These two observers have found a germ present in 

 malarial persons in the blood, which produced an intermittent 

 fever in animals which had been inoculated with such blood. 

 They were also found in the soil of the Roman Campagna. 

 Very little importance is at present attached to this germ, but 

 at the time of its discovery, 1879, it was thought to be the cause 

 of malaria. 



Hsematozoa of Malaria. Certain micro-organisms are found 

 in the blood of persons suffering from malaria, and have lately 

 been very carefully studied. They do not belong to bacteria, 

 being really of animal origin, among the protozoa; but because 

 they are described in the larger works on bacteria, it is neces- 

 sary that they be considered here. 



Synonyms. IJamutomonas Malarice (Osier). Plasmodium Ma- 

 larice (Laveran). 



Form. Various shapes have been described, and whether 

 they are all of one micro-organism or several distinct organisms 

 is not yet definitely settled. In the cell they have been found 

 intra-corpuscular, and outside of the cell extra-corpuscular. Three 

 varieties of the intra-corpuscular have been noted. 



1st. A kind without pigment, and having amoeboid movements, 

 occupying about one-third of the red corpuscle. It is probably 

 the first stage of the organism. 



2d. Pigmented amvcboid variety. The pigment probably ob- 

 tained from the blood-corpuscle, which is faded in color ; more 

 than one may be present in the same corpuscle. 



3d. The pigment set free in grains, or surrounded by large 

 homogeneous bodies which constantly change their outline. 



The extra-corpuscular bodies present several peculiar forms, 

 and are supposed to be derived from the intra-corpuscular ones. 



1st. Tlie scmilunar bodies rf Laveran ; spherical and crescent- 



