BACILLUS COLI COMMUNIS. 449 



the symptoms of enteritis, diarrhoea, etc., and finally 

 fibro-purulent peritonitis. 



When subcutaneous inoculations of mice and guinea- 

 pigs are made it requires the introduction of much 

 larger quantities of the culture to produce infection; 

 in rabbits this is followed only by abscess formation at 

 the point of inoculation. Dogs and cats are similarly 

 affected. 



Bazy and Guyon have succeeded in producing infec- 

 tion of the bladder in animals by injection of pure 

 cultures into the blood with simultaneous tying of the 

 ureters; Albaran and Halle have caused cystitis and 

 pyelonephritis by direct injections into the bladder and 

 ureters, the urine being artificially suppressed; Chassin 

 and Roger produced angiocholitis and abscess of the 

 liver in the same way. Loruelle, Fraenkel, and Bar- 

 hacci, by injuring or tying the intestines and intro- 

 ducing dirt into the abdominal cavity, with or without 

 the simultaneous injection of cultures of the colon 

 bacillus, succeeded in causing diffuse peritonitis in 

 animals. Akermann produced osteomyelitis in young 

 rabbits by intravenous injections of cultures. So far 

 all attempts to produce experimental infection of the 

 intestines by the ingestion of cultures of the colon 

 bacillus have failed to give positive results (Emmerich 

 and Korkunoff). 



Certain peculiar effects have been observed by Black- 

 stein and by Gilbert and Lion as the result of intra- 

 venous inoculation of rabbits with pure cultures of the 

 bacillus coli, which are worthy of note. The former 

 of these authors found, from eight to thirty-eight days 

 after injection, that the liver frequently contained 

 opaque, whitish or yellowish-white spots, and streaks 



29 



