MIGROGOGGUS GONORRHCEJE. 523 



generally extranuclear. When found in other portions 

 of the field this is mostly due to the mechanical effect 

 of smearing the pus on cover-glass slides, and should 

 not be considered as characteristic. That the gonococci 

 really lie within the protoplasm of the cells is proved 

 by the fact that in carefully made preparations they 

 are usually not found outside of the pus-cells. They 

 appear usually as diplococci, in groups of two or four, 



FIG. 68. 



Smear from pure culture of gonococcus on agar. (HEIMAN.) 



but at times they occur as round, single, and undivided 

 cells. Others, again, are irregular in shape or granular 

 in appearance, involution forms, particularly in older 

 cultures and in chronic urethritis of long standing. 

 The pus-cells containing gonococci are most numerous 

 in the later or purulent stage of the disease, not so fre- 

 quent in the beginning of infection, or as long as the 

 discharge is of a serous character (Fig. 69). 



The gonococcus stains readily with the basic aniline 

 colors, especially with methyl-violet, gentian-violet, and 



