MICROCOCCUS GONORRHCE^E. 



527 



pus is smeared on linen, it has lived for forty-nine 

 days, and dried on glass for twenty-nine days (Heiman). 

 No development takes place below 25 C. or above 

 39 C.; it is killed at a temperature over 42 C. 



Pathogenesis. Non-transmissible to dogs, monkeys, 

 horses, and rabbits, whether inoculations be made into 

 the urethral, vaginal, or congenital mucous membranes. 

 According to Wertheim, purulent peritonitis, not caus- 



FIG. 70. 



Colonies of gonococci on pleuritic fluid agar. (HEIMAN.) 



ing death, is produced in certain animals by the intro- 

 duction of pieces of serum-agar containing colonies of 

 the gonococcus. This effect was produced constantly in 

 mice, occasionally in guinea-pigs, and rarely, if ever, 

 in dogs, rats, and rabbits. 



Though animal inoculations are thus followed by 

 negative results, the etiological relation of the gono- 

 coccus to human gonorrhoea has been demonstrated 

 beyond question by the infection of healthy men with 

 the disease by inoculation. Thus, Bumm has produced 



