602 BA CTER10L OGY. 



brane, which characterize the disease in the horse, rarely 

 result from inoculation of the guinea-pig. The process 

 is often prolonged, or it remains localized on the skin. 

 Guinea-pigs succumb more rapidly to intraperitoneal 

 injection, usually in from eight to ten days, and in 

 males the testicles are invariably affected. 



Glanders occurs as a natural infection only in horses 

 and asses; the disease is occasionally communicated to 

 man by contact with affected animals, and usually by 

 inoculation on an abraded surface of the skin. The 

 contagion may also be received on the mucous mem- 

 brane. Infection has sometimes been produced in 

 bacteriological laboratories. In the horse, the disease 

 may be localized in the nose (glanders) or beneath the 

 skin (farcy). The essential lesion is the granulomatous 

 tumor, characterized by the presence of numerous lym- 

 phoid and epithelioid cells, among and in which are seen 

 the glanders bacilli. These nodular masses tend to break 

 down rapidly, and on the mucous membrane form ulcers, 

 while beneath the skin they form abscesses. The glan- 

 ders nodules may also occur in the internal organs. An 

 acute and chronic form of glanders may be recognized 

 in man, and an acute and a chronic form of farcy. The 

 disease is fatal in a large proportion of cases. It is 

 transmissible also from man to man. Washer-women 

 have been infected from the clothes of a patient. The 

 infective material exists in the secretions of the nose, 

 in the pus of glanders nodules, and sometimes in blood; 

 it may occasionaly be found in the secretions of healthy 

 glands, as in the urine, milk, and saliva, and also in 

 the foetus of diseased animals (Bonome). From recent 

 observations it appears that glanders is by no means 

 an uncommon disease among horses, particularly in 



