BA GILL US ICTEROIDES. 61 1 



itself particularly to experimentation with this organ- 

 ism. The virus should be injected into a vein. The 

 lesions found after death are said to be almost identical 

 with those in human yellow fever cadavers. There is 

 fatty degeneration of the liver and kidneys, accompa- 

 nied by acute parenchymatous nephritis. The digestive 

 apparatus shows lesions of hemorrhagic gastro-enteritis. 

 The bacilli are found in the blood and the organs in 

 variable quantity and in a state of absolute purity; at 

 times, they may be associated with the B. coli and the 

 streptococcus. 



The disease may be transmitted experimentally even 

 by the respiratory tract to rabbits and guinea-pigs; the 

 bacteriological examination of these cases shows, at 

 least, the existence of toxic processes similar with that 

 which takes place in man. The toxin is obtained by 

 filtering twenty to twenty-five days' old cultures in 

 broth. It withstands a temperature of 70 C., but is 

 sensibly weakened by boiling. 



According to Sanarelli, infection in the human sub- 

 ject does not take place by the digestive but by the 

 respiratory tract; and he suggests that the common 

 moulds of the atmosphere may constitute protectors of 

 the bacillus icteroides. 



Sanarelli has also prepared a protective or curative 

 serum for the treatment of the disease, which he calls 

 " anti-amarylic serum." This serum has not been 

 sufficiently tested as yet to form any definite conclu- 

 sions as to its value ; but because of its not being an 

 antitoxin, it does not tend to overcome the toxins of 

 yellow fever produced in the system, and depends for 

 its curative and prophylactic properties upon its germi- 

 cidal influence. Hence, it is argued by Sanarelli that 



