APPENDIX. 



recorded in cats, in all of which an experimental dysen- 

 tery was produced. The lesions found are reddening 

 and swelling of the intestinal mucosa, chiefly of the 

 lower half of the large bowel, with here and there 

 ecchymoses, small, superficial areas of necrosis, and 

 shallow ulcerations. The mesenteric glands and the 

 solitary lymphoid follicles are often swollen. In the 

 blood-tinged mucus covering the mucous membranes 

 amoebae are found in greater or less numbers. Micro- 

 scopical examination of sections of the intestine shows 

 that the necrosis is limited, as a rule, to the mucosa, 

 and that beneath it the submucosa is thickened and 

 oedematous and its vessels engorged; there is also small- 

 celled infiltration. Amoebae are found in the borders 

 of the ulcers, chiefly in the follicles of Lieberkiihn; 

 in the base of the ulcers they rarely penetrate more 

 deeply than the upper layers of the submucosa. With 

 the amoebae are found many bacteria, chiefly streptococci. 

 From a comparison with the lesions of amoebic dysen- 

 tery in man it will be seen that while the processes in man 

 and in the cat are not identical, more especially as re- 

 gards the depth and extent of the ulceration, yet in many 

 points the resemblance is striking. A series of control 

 experiments was undertaken, by the authors quoted, 

 with amoebae from the stools of healthy individuals and 

 the straw-infusion amoeba of Kartulis obtained in his 

 culture experiments. In neither of these cases could 

 an experimental dysentery be produced in any of the 

 animals inoculated. They conclude that it is proper 

 to designate the pathogenic amoeba as the amoeba dys- 

 enterice (Councilman and Lafleur), and to retain the name 

 amoeba coli (Losch) for the non-pathogenic amoeba of 

 the normal healthy intestine. 



