RABIES. 667 



was the u simple" ten-day method. It was soon evident 

 that although this method was efficacious where the 

 wounds were not severe, and were confined to parts in 

 which the nerve-supply was not extensively interfered 

 with, it was often quite inadequate in serious cases, 

 as of wounds about the face, or of wounds inflicted 

 by a mad wolf, the virus of which is more active and 

 the lesions made more severe than that of the rabid 

 dog of the streets. In these latter cases the injec- 

 tions which, iu the simple treatment, are spread over 

 five days are made in three days; then, on the four- 

 teenth day, a fresh series of injections, or, rather, repe- 

 titions, is begun, which lasts until the twenty-first day. 

 This is the " intensive method." In the technique of 

 the treatment, which is the same in both methods, a 

 small portion (about 1 cm.) of the desiccated cord is 

 rubbed up thoroughly with about four or five times its 

 bulk of bouillon until a complete emulsion is made; 

 this, then, is injected by means of a syringe, holding 

 several cubic centimetres, first on one side of the hypo- 

 chondriac region and then on the other, the following 

 day, and so on alternately, to avoid irritation. With 

 the observance of thorough asepsis no local reaction to 

 speak of takes place, nor are abscesses ever formed. 

 The results of Pasteur's method of protective inocula- 

 tion, as recorded in the reports issued in the Annales de 

 rinstitut Pasteur and those of other antirabic institutes 

 in Italy, Russia, Roumania, etc., are very favorable. 

 Since 1886, when the treatment was first commenced at 

 the Pasteur Institute in Paris, upward of 20,000 per- 

 sons bitten by rabid, or presumably rabid, animals have 

 received preventive inoculations, with a mortality of 

 only 0.5 of 1 per cent. The mortality of those bitten 



