NATURAL OCCURRENCE OF GLANDERS. 241 



firm, though suppurative softening usually follows, and there 

 may be ulceration. These thickenings are often spoken of 

 as farcy buds and farcy pipes. In farcy also, secondary 

 nodules form, and internal organs and the nasal mucous 

 membrane may be thus affected. In the ass the disease 

 runs a more acute course than in the horse. 



In man the disease is met with in two forms, an acute and 

 a chronic, though intermediate forms also occur, and chronic 

 cases may take on the characters of the acute disease. 

 The site of inoculation is usually on the hand or arm, by 

 means of some scratch or abrasion, or possibly along a hair 

 follicle, sometimes on the face, and occasionally on the 

 mucous membrane of the mouth, nose, or eye. In the acute 

 form there appears at the site of inoculation inflammatory 

 swelling, attended often with spreading redness, and the 

 lymphatics in relation to the part also become inflamed, 

 the appearances being those of a " poisoned wound." 

 These local changes are soon followed by marked con- 

 stitutional disturbance, and by an eruption on the surface 

 of the body, at first papular and afterwards pustular, and 

 later there may be in the subcutaneous tissue and muscles 

 larger masses which soften and suppurate, the pus being 

 often mixed with blood, and suppuration may occur in the 

 joints. In some cases the nasal mucous membrane may 

 be secondarily infected, and thence inflammatory swelling 

 may spread to the tissues of the face ; in others it remains 

 free. The patient usually dies in two or three weeks, 

 sometimes sooner, with the symptoms of rapid pyaemia. 

 In addition to the lesions mentioned there may be foci, 

 usually suppurative, in the lungs (attended often with 

 pneumonic consolidation), in the spleen, liver, bone- 

 marrow, salivary glands, etc. In the chronic form the local 

 lesion results in the formation of an irregular ulcer with 

 thickened margins and sanious, often foul, discharge. The 

 ulceration spreads deeply as well as superficially, and the 

 thickened lymphatics have a great tendency to ulcerate 

 also, though the lymphatic system is not so prominently 

 affected as in the horse. Deposits form also in the sub- 

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