EXPERIMENTAL ANTHRAX. 



285 



show changes, a fact which is important when we consider 

 the essential pathology of the disease. 



Experimental Inoculation. Of the animals commonly 

 used in laboratory work, white mice and guinea-pigs are the 

 most susceptible to anthrax, and are generally used for 

 test inoculations. If a small quantity of anthrax bacilli 



9 ' &* 









FIG. 75. Portion of kidney of a guinea-pig dead of anthrax, showing 

 the bacilli in the capillaries, especially of the glomerulus. 



Paraffin section; stained by Gram's method and Bismarck -brown. 

 X300. 



be injected into the subcutaneous tissue of a guinea- 

 pig, a fatal result follows, usually within two days. Post 

 mortem around the site of inoculation the tissues are swollen 

 and gelatinous in appearance, owing to intense inflammatory 

 oedema, and on microscopic examination show numerous 

 bacilli. The internal organs show congestion and cloudy 



