340 BACTP:RIOLOGY. 



of septicaemia. In such sections the organisms will 

 always be found within the capillaries. 



INOCULATION INTO ANIMALS. To the naked eye 



no alteration can be seen in the organs of animals that 



O 



have died as a result of inoculation with sarcina 

 tetragena ; but microscopic examination of cover-slip 

 preparations from the blood and viscera reveals the 

 presence of the organisms throughout the body espe- 

 cially is this true of preparations from the spleen. 

 White mice and guinea-pigs are susceptible to the dis- 

 ease. Gray mice, dogs, and rabbits are not susceptible 

 to this form of septicaemia. Subsequent inoculation of 

 healthy animals with a drop of blood, a bit of tissue, or 

 a portion of a pure culture of this organism from the 

 body of an animal dead of this disease, results in a re- 

 production of the conditions found in the dead animal 

 from which the tissues or cultures were obtained. 



It sometimes happens that in guinea-pigs which have 

 been inoculated with this organism local pus-formations 

 result, instead of a general septicaemia. The organisms 

 will then be found in the pus-cavity. 



BACTERIUM INFLUENZA (R. PFEIFFER) LEHMANN 



AND NEUMANN, 1896. 



Synonym: Influenza bacillus, R. Pfeiffer, 1892. 



An important historic epidemic disease, on the nature 

 of which much light has been shed through modern 

 methods of investigation, is influenza. Quoting Hirsch, 

 the first trustworthy literary records that we have of 

 this disease date from the early part of the twelfth 

 century. 



Between 1173 and 1874 it made its epidemic or pan- 



