COVEE-SLIPS AND SECTIONS. 251 



seen to be more advanced in some of the elements of 

 the tissues than in others. As we approach the periph- 

 ery of this faintly stained necrotic area it becomes 

 marked here and there with granular bodies, irregular 

 in size and shape, which stain in the same way as do the 

 nuclei of the pus- cells and represent the result of dis- 

 integration going on in these cells. 



Beyond this we come upon a dense, deeply stained 

 zone, consisting of closely packed pus-cells; of granular 

 detritus resulting from destructive processes acting upon 

 these cells ; and of the normal cellular and connective- 

 tissue elements of the part. Here and there through 

 this zone will be seen localized areas of beginning death 

 of the tissues. This zone gradually fades away into 

 the healthy surrounding tissues. It constitutes the so- 

 called " abscess-wall." 



Such is the picture presented by the miliary abscess 

 when produced experimentally in the rabbit, and it cor- 

 responds throughout with the pathological changes 

 which accompany the formation of larger abscesses in 

 the tissues of human beings. 



From these small abscesses in the tissues of the rab- 

 bit the staphylococcus pyogenes aureus may again be 

 obtained in pure culture, and will present identically 

 the same characteristics that were possessed by the cul- 

 ture with which the animal was inoculated. 



THE LESS COMMON PYOGENIC ORGANISMS. The 

 pus of an acute abscess in the human being may some- 

 times contain other organisms beside the staphylo coccus 

 pyogenes aureus. The staphylococcus pyogenes albus 

 and citreus may be found. The colonies of the former 

 are white, those of the latter are lemon-color. With 

 these exceptions they are in all essential cultural peculi- 



