THE BACILLUS OF GLANDERS. 317 



the tendency is toward an amalgamation of its histo- 

 logical constituents, and ultimately to necrosis with 

 caseation. The giant-cell formation common to tuber- 

 culosis is never seen in the glanders nodule. As 

 Baumgarten aptly puts it: " The pathological mani- 

 festations of glanders, from the histological aspect, stand 

 midway between the acute purulent and the chronic in- 

 flammatory processes. ? ' l Evidently these differences are 

 only to be explained by differences in the nature of the 

 causes that underlie the several affections. We have 

 studied the characteristics of bacillus tuberculosis; we 

 shall now take up the bacillus of glanders and note the 

 striking differences between them. 



THE BACILLUS OF GLANDERS (bacillus mallei). In 

 1882 Loeffler and Schiitz discovered in the diseased tis- 

 sues of animals suffering from glanders a bacillus that, 



FIG. 64. 



x 



& 



Bacillus of glanders (bacillus mallei). 



when isolated in pure culture and inoculated into sus- 

 ceptible animals, possesses the property of reproducing 

 the disease with all its clinical and pathological mani- 

 festations. It is therefore the cause of the disease. 



1 For a further discussion of the pathology and pathogenesis of this disease 

 see Lehrbuch der pathologischen Mykologie, by Baumgarten, 1890. See, also, 

 Wright : The Histological Lesions of Acute Glanders in Man. Journal of Ex- 

 perimental Medicine, vol. i. p. 577. 



