CHAP. II.] 



GLANDS OF THE FUNDUS. 



105 



rennet-ferment. When acidulated with HC1 it digests fibrin abun- 

 dantly. It contains no diastatic ferment. 



These experiments have ^conclusively proved that the glands of 

 the pyloric region of the stomach take some part in the formation of 

 pepsin, though of the total amount secreted by fundus and pylorus, 

 the latter is unimportant compared with the former. 



THE GLANDS OF THE FUNDUS. THE CELLS WHICH PRODUCE PEPSIN 

 AND THE CELLS WHICH PRODUCE ACID. 



By a procedure similar to that which he employed in establishing 

 in a living animal a tube composed of the pyloric portion of the 

 stomach, Heidenhain succeeded in separating from its continuity with 

 the rest of the stomach a part of the fundus and stitching it into the 

 form of a tube, of which he connected the opening with the external 

 abdominal wall. In one case an animal which had been subjected 

 to this operation lived for 33 days and allowed Heidenhain to collect 

 the pure secretion of the fundus. 



A few minutes after introduction of food into the stomach, 

 secretion commenced in the sac and continued throughout the whole 

 period of digestion. The fluid secreted was watery, of acid reaction, 

 and contained pepsin ; it had, in short, all the characters of gastric 

 juice. 



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FIG. 8. CURVE EXHIBITING THE AMOUNT OF PEPSIN IN A GIVEN AMOUNT OF THE 

 SECRETION OF THE FUNDUS, DURING SUCCESSIVE HOURS OF THE DIGESTIVE PROCESS 

 (HEIDENHAIN). 



Whilst the pyloric glands thus secrete an alkaline liquid con- 

 taining pepsin, the glands of the fundus secrete both pepsin and acid. 

 The question then suggests itself, Where is the seat of the formation of 

 pepsin, and where that of the formation of acid ? It has already been 



