410 CONDITIONS INFLUENCING SECRETION OF INTES. JUICE. [BOOK II. 



Electrical stimulation of the mucous membrane powerfully 

 excites the flow of intestinal juice (Thiry), but here again it is 

 obvious that we have no guarantee that the liquid secreted preserves 

 its normal characters. 



Effects of Leuret and Lassaigne applying acetic acid to the 

 chemical sti- intestinal mucous membrane observed secretion to 



muiationofthe fo n ow i. The researches of F. Rohmann have proved 



mucous mem- -, . -, ,-, , ,. P , 



brane. verv conclusively that solutions of starch, sugars and 



peptones into the intestine provoke the secretion of 

 intestinal juice, and these observations the Author can independently 

 confirm. 



Effects of pi- By injecting pilocarpin into the blood, Vella, and 

 locarpin on the afterwards Masloff, obtained a tolerably abundant flow 

 Se ~ ^ a PP arent ty normal intestinal juice. In a dog with a 

 fistula, Vella obtained, under the influence of pilocarpin, 

 14 c.c. of intestinal juice in 35 minutes, and on another occasion 

 18 grms. in one hour. Masloff, after an injection of O'Ol grm. of 

 hydrochlorate of pilocarpin, obtained from one fistula 40 c.c. of succus 

 entericus in 2 hours. That the result is one which is not obtained 

 under all conditions is shewn by an experiment made by the Author. 

 To a dog, with a Vella fistula of the upper part of the jejunum, but 

 which had been fasting for 24 hours, he administered 0'07 grm. of 

 hydrochlorate of pilocarpin by subcutaneous injection, and although 

 abundant salivation with flow of the nasal and lachrymal secretions 

 occurred, no secretion whatever of intestinal juice followed. The 

 anomalous result in this case may have been due either to the fact 

 that the portion of the intestine experimented upon was situated 

 at the very commencement of the jejunum, whilst in Vella' s and 

 Masloff's cases it was probably low down, or that in the fasting 

 condition, the intestine is unable to secrete intestinal juice, even 

 under the influence of pilocarpine 2 . 



influence of Thiry found that stimulation of the vagi had no 



nervous system effect Qn the secret ion of intestinal juice. Budge 3 



secretion 8 Mo- observed after extirpation of the coeliac and mesenteric 



reau's expert- plexuses an increase of the secretion. His observations 



ment. Paraly- were confirmed by Lamansky 4 , though Adrian 5 obtained 



tic secretion. negative results in the case of dogs. Subsequently, 



1 Leuret et Lassaigne, Recherches physiologiques et cliimiques pour servir a Vhistoire 

 de la digestion, 1825, p. 141, quoted by Heidenhain, loc. cit. p. 171. 



2 The Author has since the experiment above recorded was performed repeated it, 

 the only variation being that the animal was in full digestion. In this case pilocarpin 

 certainly provoked a visible secretion, but the amount was so scanty as not to admit of 

 the quantity being determined. This case unquestionably supports Kohmann's belief 

 that the quantity of intestinal juice secreted by the lower part of the small intestine is 

 much greater than that secreted by the upper (Aug. 1893). 



3 Budge, Verhand. d. k. k. Leopold-Carol Acad. d. Naturforscher, Vol. xix. (1860), 

 p. 250. 



4 Lamansky, Zeitschr. f. rat. Med. 1866, p. 59, quoted by Heidenhain. 



5 Adrian, Eckhardt's Beitrdge z. Anat. u. Phys., Vol. m. (1863), p. 61. 



