522 



INDEX. 



195 ; quantity of, secreted, 199 ; physical 

 and chemical characters of, 199, 200 ; 

 general chemical characters of, 200 ; the 

 enzymes which it contains, 201 ; con- 

 tains no tyrosine, and only a trace of 

 leucine, 201 ; percentage composition of 

 the juice of recent fistulas, 201 ; of the 

 thin juice of permanent fistulas, 202; 

 C. Schmidt's analyses of, from temporary 

 and from permanent fistulas, 202 

 Pancreatic juice : The Enzymes of, 202 



I. The diastatic enzyme, 203 ; pre- 

 paration of solutions of, 204, 205 ; mode 

 of action of, 205 ; how affected by tem- 

 perature, 206 ; influence of quantity of, 

 on rate of diastatic action, 206; ap- 

 proximate estimate of diastatic power of 

 the ferment itself, 206 ; relative richness, 

 in enzyme, of the pancreas of ox, sheep, 

 pig, 206; is there a zymogen of?, 206; 

 independent of the other pancreatic en- 

 zymes, 208; attempts to isolate, 208, 

 209 ; ultimate analyses of, 210 



II. The fat-splitting enzyme of, 210; 

 researches of Claude Bernard, 210 et 

 seq. ; in virtue of, the pancreatic juice 

 and the fresh gland-tissue itself decom- 

 pose the neutral fats, 212 ; how to 

 demonstrate this action, 213 ; property 

 lost when tissue becomes acid, 213; 

 Griitzner's method of preparing, 214 ; 

 of observing comparative fat-splitting 

 activity; property of, to decompose acetic 

 ether, 214 ; reasons for asserting that a 

 fat-splitting enzyme exists, 215 ; Griitz- 

 ner's observations on the richness of the 

 pancreas in fat-decomposing enzymes, 

 215 



III. Trypsin, the proteolytic enzyme, 

 216 ; historical notes on the discovery 

 of the proteolytic activity of the pancreas 

 and its secretion, 216 ; the zymogen of, 

 219 ; synonyms of, 220 ; methods of 

 preparation of, 220 ; properties of, 221 ; 

 preparation of solutions of, 221, 222 



Proteolysis by, conditions necessary 



to, 222 ; general phenomena of, 223 ; pri- 

 mary products of, and their amounts, 

 225 ; normal trypsin-digestion not asso- 

 ciated with evolution of gases, 225 ; 

 1 antipeptone ' or ' tryptone,' mode of 

 preparation, reactions of, 227; com- 

 parative reactions of fibrin, anti-peptone 

 and fibrin ampho-peptone, 228 



Pancreatic secretion, general phenomena 

 of, 195 ; influence of the nervous system 

 upon, 196 



' Pancreatin,' term applied to a mixture 

 of the pancreatic enzymes, 208 



' Pancreatinine,' a synonym of pancreatin 



PANUM referred to, concerning gastric 

 fistula, 73, 75 ' 



Para-hydrocumaric (paroxyphenylpropi- 

 onic acid), 248 



Parakresol, 248, 432; properties and 

 identification of, 434 ; behaviour in the 

 economy, 435 



' Paralytic ' submaxillary saliva, 32 



Para-ethylphenol, 248 



Para-oxybenzoic acid, 248 



Para-oxyphenyl-acetic acid, 248, 430 



Para-oxyphenyl-a-amidopropionic acid, or 

 tyrosine, 247 



Para-oxyphenyl-propionic acid, 247, 429 



1 Parapeptone,' Meissner's statements in 

 reference to, 115 



PARKE, J, researches of, on taurocholic 

 acid, 300 



PARKINSON, synthesis of leucine, 239 



Parotid duct, see Saliva 



Parotid gland, see Saliva 



PASCHKIS, 011 cholagogues, 374 



PASCHUTIN, V., action of intestinal juice 

 on proteids, 413 ; discovery of ' inverting 

 ferment ' of small intestine, 414 ; on 

 fermentations in the intestines, 466 



PASTEUR, his researches on fermentation, 8 



Pathogenic organisms, destruction of, by 

 the acid of the gastric juice, 171, 172 



PATON, D. NOEL and JOHN M. BALFOUR, 

 case of biliary fistula in a woman recorded 

 and investigated by them, 275, 345, 

 346 ; diminution and absence of bile 

 colouring matter, during pyrexia, 368 



PATON, D. NOEL, second set of observations 

 on the woman with biliary fistula pre- 

 viously investigated by J. M. Balfour 

 and himself, 275, 277 



PAVY, F., his explanation of the non- 

 digestion of the stomach by the gastric 

 juice, 161 



PAWLOW, M., experiments of, on influence 

 exerted by atropia on pancreatic secre- 

 tion, 197 ; experiments with M. Hahn, 

 v. Massen and M. Nencki on dogs, in 

 which he established a fistulous aperture 

 between the portal vein and the vena 

 cava inferior, 385 



PAIJKULL, researches of, on the mucoid 

 nucleo-albumin of bile, 336 



PAYEN and PERSOZ on diastase, 5 



PEIPER, on the excretion of drugs by the 

 bile, 375 



PELOUZE, on the nature of the acid of the 

 gastric juice, 91 



PELOUZE and DUMAS, report of the French 

 Academy, on the researches of Demarcay 

 on the bile, 293 



Penta-methylendiamin or cadaverin, 436 



Pepsin, 85 ; methods of preparation ; 

 Schwann's,85; Wasmann's,85; Briicke's, 

 86 ; v. Wittich's, 87 ; purification of, by 

 dialysis, 88 ; commercial preparation of, 

 90 ; indiffusibility of, 88, 89 ; principal 

 seat of formation of, in frog, in oesopha- 

 gus, 107; determination of activity of, 

 182 ; destruction of, 443 



Pepsinogen, 101; first observations of 



