0141612 



ranged from 0.09 to 0.26 ppm (mean 0.15) in six lambs analyzed by 

 Bucy et al. (1955). Puis (1981, 1985) has given a range of 0.01 to 

 0.3 ppm for normal arsenic levels in sheep kidney tissue. 



Arsenic levels in normal liver tissue from cattle have been 

 reported as 0.013 ppm (n = 190) and 0.06 ppm (n = 100) by Flanjak 

 and Lee (1979) and Doyle and Spaulding (1978), respectively. 

 Normal ranges for cattle liver have been given as 0.03-0.40 ppm 

 (Puis 1981) and less than 0.5 ppm (NRC 1977). Buck et al. (1976) 

 has stated normal levels are usually less than 0.5 ppm. Background 

 arsenic levels in sheep liver have been reported as 0.03 ppm for 

 440 animals tested by Spaulding (1975), and 0.05 to 0.21 ppm (mean 

 0.15 ppm) for six lambs studied by Bucy et al. (1955). Normal 

 sheep liver levels given by Puis (1981) are 0.03 to 0.20 ppm. 

 Horse liver and kidney background levels of less than 0.4 ppm have 

 been reported by Puis (1981). 



Insufficient data exist to determine background levels of 

 arsenic in spleen tissue, but limited data suggest that in some 

 cases elevated arsenic concentrations in the spleen may be higher 

 than in liver or kidney tissue (Table 4). 



Elevated arsenic levels in kidney, liver and spleen have been 

 demonstrated in a number of experimental and accidental situa- 

 tions. Peoples (1964) found concentrations greatest in the spleen 

 (2.0 ppm) and liver (1.2 ppm) of cattle fed 1.25 mg/kg arsenic 

 acid for eight weeks. Bucy et al . (1955) found arsenic concentra- 

 tions nearly equal in the kidneys and liver of lambs fed up to 0.4 

 percent of their diet as organic arsenic compounds. Levels were 

 sharply elevated from background concentrations with diets of 500 

 ppm organic arsenic content. Cattle kidney levels as high as 53 

 ppm have been reported by Underwood (1977). 



The level at which chronic poisoning -occurs has not been well 

 documented. Reduced weight gains, which are only rarely noticed, 

 are generally the first signs of chronic arsenic poisoning. 

 Increasing levels to 1000 ppm arsanilic acid in the diet of swine 

 produced posterior paresis or quadriplegia in 15 days (Ledet et 

 al. 1973). Levels of 7.5 to 7.8 and 6.8 to 12.3 ppm (wet weight) 

 for kidneys and liver, respectively, were noted in sheep fed 0.05 



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