182 THE URINE. 



GLOBULIN, ALBUMOSE, AND PEPTONES. 



Globulin is found in the urine only with albumin. 

 It passes into the urine in much the same manner, and 

 has no especial diagnostic value. 



385. To 10 cubic centimeters of the clear urine (fil- 

 tered if necessary) add an equal volume of a saturated 

 solution of ammonium sulphate. The serum globulin will 

 be precipitated, but not the albumin. 



386. Saturate the clear urine with finely powdered 

 magnesium sulphate without warming. Serum globulin 

 is precipitated. This can be removed by filtration and 

 confirmed by the usual tests for globulins. 



Albumose may be formed in urine by bacterial action 

 from albumin. It may easily escape discovery, since it is 

 not coagulated by heat. It is often the precursor of albu- 

 min, and, as such, a knowledge of its presence is impor- 

 tant. Before testing for its presence the other albuminous 

 substances must be removed. After removing albumin by 

 boiling the liquid slightly acidified by acetic acid, albumose 

 can be detected by its giving a precipitate upon saturation 

 with sodium chlorid, which dissolves on heating and re- 

 appears on cooling. 



The results of the latest research have shown that 

 much of what has been regarded as peptone in urine is one 

 of the albumoses which closely resembles it, and it is an 

 open question whether peptones are ever found in this ex- 

 cretion. Nevertheless we may temporarily retain the name 

 peptonuria for the condition, with the understanding that, 

 as our knowledge becomes greater, it may have to be aban- 

 doned. The peptones or albumoses are not normally found 

 in the blood, being converted in the intestinal mucous 



