12 



MASS. EXPERIMENT STATION BULLETIN 391 



Table 7. — Degree of Involvement of Organs and Tissues in 213 Cases of 



Lymphocytoma. 



Figures express percent of affected organs or tissues having the respective 

 degree of involvement. Figures in parentheses are the number of cases in which 

 the organs or tissues were affected with lymphocytoma. 



Organs or Tissues 

 Involved 



Number 



of 

 Cases 



Grade 1 



Degree of Involvement*' 



Grade 2 



Grade 3 



Grade 4- 



Liver 



Spleen 



Kidney 



Gonad 



Marrow 



Lung 



Peritoneum 



Skin and Subcutis. . . . 



Musculature 



Thymus 



Adrenal 



Heart 



Pancreas 



Intestine 



Bursa of Fabricius. . . . 



Proventriculus 



Blood 



Nerves 



Anterior mesenteric. 



Brachial 



Lumbar 



Ischiadic 



Vagus 



of Remak 



116) 

 93) 

 108) 

 112) 

 (42) 

 41) 

 64) 

 17) 

 18) 

 11) 

 62) 

 24) 

 26) 

 42) 

 24) 

 22) 

 45) 



50) 

 47) 

 43) 

 23) 

 23) 

 20) 



9 

 23 



21 

 5 

 35 

 15 

 13 



17 

 27 

 24 

 17 

 8 

 14 



14 

 44 



24 

 21 

 12 



4 

 5 



16 

 21 

 26 

 11 



24 

 22 

 23 

 6 

 II 

 27 

 24 

 17 

 12 

 19 



41 

 40 



16 



11 

 16 

 13 

 17 

 20 



27 

 28 

 35 

 16 

 17 

 39 

 22 

 29 

 17 

 19 

 28 

 53 

 38 

 28 

 13 

 31 

 16 



30 

 30 



47 



44 



•48 



45 



48 

 28 

 18 

 68 

 24 

 24 

 42 

 65 

 55 

 27 

 24 

 13 

 42 

 39 

 87 

 14 



30 

 38 

 25 

 43 

 31 

 30 



*Graded from 1 to 4, with Grade 1 representing a small amount of tumor and Grade 4 heavjr 

 infiltration. 



Estimation of the degree of inv^olvement of the blood was difficult to make 

 and subject to considerable error. The recognition of a neoplastic lymphoid 

 cell in the blood stream represents a problem in itself. Most of the observations 

 on the condition of the blood were made by noting the blood contained in the 

 vascular bed of the sections of tissue at the time of histological examination. 

 The presence of lymphoid cells resembling those found in areas of lymphocytoma 

 in the lumen of blood vessels was taken to represent involvement of the blood 

 stream. In some instances actual erosion of a vessel wall located within a mass 

 of tumor was found and obviously such an erosion would permit a mechanical 

 washing of tumor cells into the circulation. It was necessary to exercise consid- 

 erable care in some cases to distinguish between a leukocytosis of heterophils 

 or lymphocytes and abnormal numbers of tumor cells in the blood. 



There were only slight differences in the degree of involvement of the different 

 forms of lymphocytoma (Table 8). Grade 4 involvement was noted more fre- 

 quently in cases of nodular lymphocytoma and least often in the combined diffuse 



