CONTAGIOUS DISEASES OF DOMESTICATED ANIMALS, 81 



same rod-shaped organisms as mentioned above ; tliey are cliiefly in spaces between 

 the bundles of the intiamed connective tissue, forming hei'e streaks of longer or shorter 

 chains. (Page 42.) 



lu his first report this was stated as follows: 



In the ulceration of the tongue just mentioned, and at a time when the superficial 

 scab has not been i-emoved, I have seen masses of micrococci situate chiefly in the tissue 

 of the papilhe, but at some places reaching as far deep as the inflammation extends. 

 (Page 99.) 



In regard to the similar lesions of the epiglotis the following lan- 

 guage was used : 



I have before rue preparations through the epiglottis, the submucosa of the pos- 

 terior surface being in a state of necrosis, and near the edge so broken down as to 

 eave there a deep ulcer, while the mucous membrane of the anterior surface is only 

 slightly inflamed in its submucous tissue ; in this 1 find lymphatic vessels filled with 

 micrococci, &c. (Pau;e 100.) 



As to the appearance of the lung his last report says : 



Sections through the diseased ])arts of the lung reveal, in preparations stained as 

 above, the iireseuce of large numbers of micrococci in the cavity of the bronchi and 

 air vesicles, but not in all lungs, since I have fouud lungs in which they were alto- 

 gether absent. But there are always present in larger or smaller clumps the same 

 minute rod-shaped organisms as mentioned above. They are imbedded in a coagulum 

 filling the air vesicles, or they block up a blood-vessel in the wall of a bronchiole or 

 air vesicle. In the air vesicles I have seen exudation cells, white-blood corpuscles coa- 

 taining clumps of the rods ; they are well brought out by Spiller's ptirple. In the air 

 vesicles of some lungs I have seen them grow to very long chains, leptotbrix, ten, 

 twenty, and more times the leiigth of the single rods. These rods were present, not 

 only in the air vesicles, but also in the tissue itself, both of the walls of the air vesicles 

 as well as of the smaller or larger bronchi. (Pages 41, 42.) 



In his first report there is a most radical difference in the description 

 of the situation where the micrococci were seen : 



In the infiltrated, firm, more or less disintegrating parts I find great masses of mi- 

 crococci filling up capillaries and veins, and also con tainedinlj'uiphaticsaround arteries. 

 They may be found also in minor bronchi which have been completly blocked up by 

 cheesy inflammatory products, but there the masses of micrococci, conspicuous by 

 |heir blue coloration in ha*matoxylin preparations, are generally present in greater or- 

 smaller lumps between the outer surface of the plug and the wall of the bronchus. 



The pleura is much swollen, and contains great numbers, continuous layers, of lumps 

 of micrococci. The free surface of the membrane is in many parts covered with them. 

 The exudation fluid is also charged with them, as has been mentioned above. (Pages 

 100.101.) 



That is to say, in 187G, Dr. Klein was able to tind the micrococci not 

 Hilly in the necrotic parts of the ulcerations, but he found them from and 

 hc/'orc the first s!(/ns of ufcrosls; he found them extend in(/ as deep into the 

 tissue of the tont/ne as the injianimation extended, and in the epiglottis at 

 I' point ichere the submucous tissue was only slightly inflamed he found the 

 lijinphatic vessels filed, ivith mieroeocei. lu the lungs, instead of the 

 iiiicTococci being confined to the cavity of the air vesicles and bronchj 

 as he desires us to understand from his last report, he really found them 

 /■// the infiltrated and firm parts, filling up capillaries, reins and lymphatics, 

 Tliey had even penetrated to the pleura ichich contained great numbers 

 5751 D A V) 



