INFECTKUS DISEASES, 549 



tion. i-emainin<x for soimo tiiiu' as a loral sort*, ^\hic•ll may thrn Ileal, 

 leavin*; a perfectly souiul animal; but while the local sure is con- 

 tinuing to ulcerate, and specific virus exists in it, it may be the car- 

 riei- of contajrion to other animals. In man we find a *rreater recep- 

 tivity to glanders than in the dog, and in many unfortunate cases 

 the virus spi'eads from the point of inoculation to the entire system 

 and destroys the wretched mortal by extensive ulcers of the face and 

 hemorrhage or by destruction of the lung tissue: in otiier cases, 

 however, glanders may develoji, as in the dog. in local form only, 

 not infecting the constitution and terminaling in recovery, while the 

 specific ulcer by proper treatment is turned into a simple one. In 

 the feline species glanders is more destructive than in the dog. The 

 point of inoculation ulcerates rapidly and (he entire system becomes 

 infected. 



AVhile a student the writer saw a lion in the seT\ ice of Prof, 

 Trasbot. at Alfort, which had contracted the disease by eating glan- 

 dered meat and died with the lung riddled with nodules. A litter of 

 kittens lapped the blood from the lungs of a glandered horse on which 

 an autopsy was being made, and in four days almost their entire 

 faces, including the nasal bones, were eaten away by rapid ulcera- 

 tion. Xodules were found in the lungs. A pack of wolves in the 

 Philadelphia Zoological Garden died in 10 days after being fed with 

 the meat of a glandered horse. The rabbit, guinea ])ig, and mice 

 are especially suscejitible to the inoculation of glanders, and these 

 animals are convenient witnesses and proofs of the existence of sus- 

 pected cases of the glanders in other animals by the results of suc- 

 cessful inoculations. 



The primary lesion in any form is a local point in which occurs 

 a rapid proliferation of the cell elements which make up the aniuial 

 tis.sue with formation of new connective tissue, with a crowding to- 

 gether of the elements nntil their own pressure on one another cuts off 

 tlie circulation and nutrition, and death takes place in them in the 

 form of ulceration or graiigrene. Following this primary lesion we 

 have an extension of infection by means of the spread of the bacilli 

 into those tissues imme<liately' surrounding the first infected s)>ot, 

 which are most suital'le for the de\('loi)uient of simple inflauimatory 

 phenomena or the sj^cific virus. The primary symptoms are the re- 

 sult of specific i-eaction jit the point of inoculation, but at a later time 

 the \irus is cariMe<l l»y means of the blood vessels and lyiii|)liatic ves- 

 sels to other parts of the body and becomes lodged at different places 

 and develops in them: again, when the disease has existed in the 

 latent form in the lungs of the animal and the virus is wakened into 

 action from any cause, we have it caiiied to \ aiious parts of the body 

 and developing in the most susceptible regions or organs. The points 

 of development are most fie<|ueiitly deteiiuined by the activity of the 



