io6 THE GROUSE DISEASE chap, xii 



but no result was obtained ; the animals remained 

 alive and well. 



lo. Mice (two in number) were inoculated under 

 the skin of the back with a large dose of a gelatine 

 culture of the heart's blood of an Orpington fowl. 

 Both animals were found ill after twenty-four hours ; 

 coat rough, "lumpy," breathing rapid. After forty- 

 eight hours the animals were worse, very quiet, eyes 

 closed. After three days they were so bad that they 

 looked dying. One died during the day. On post- 

 mortem examination the liver was found congested, 

 the spleen dark and distinctly enlarged ; no other 

 change. Cultivations were made of the heart's blood 

 and the spleen juice, but on incubation only a few 

 colonies of a liquefying coccus were found, no colonies 

 of the bacillus of fowl enteritis. The second mouse 

 was still ill, but alive on the fifth day : it was killed, 

 and cultivations were made of the heart's blood and 

 the spleen tissue, but no colonies of any bacteria made 

 their appearance. I take it, then, that the two mice 

 were made ill on account of having injected into them 

 a large dose of the chemical products of the bacilli, 

 the bacilli themselves not surviving or multiplying in 

 the body of the mouse, and therefore the mouse must 

 be also considered as refractory to the bacillus of fowl 

 enteritis, altogether different from fowl cholera, to 

 which illness mice are very susceptible. 



