SECRETION. 



not been isolated, hence its chemic features are unknown. After its 

 formation it probably passes through a system of ducts into the 

 cerebrospinal fluid, after which it influences the metabolism of the 

 nerve and osseous tissues as well as the. force of the heart muscle. 



An extract of the^ajiterior loje itsdf exerts no aprjredable effect 

 on the blood-pressure or on die rate " 



fluence the circulatory and respiratory organs. Anextractofthe 

 infundibular body intravenously injected, how- ~' 

 ever, gives rise to increased blood-pressure and 

 to a 'slowing of the heart-beat (Ho well). 



Adrenal Bodies, or Suprarenal Capsules. 

 These are two flattened bodies, somewhat cres- 

 centic or triangular in shape, situated each upon 

 the upper extremity of the corresponding kidney, 

 and held in place by connective tissue. They 

 measure about 40 mm. in height, 30 mm. in 

 breadth, and from 6 to 8 mm. in thickness. The 

 weight of each is about 4 gm. 



Function^ of the Adrenal Bodies. It was 

 observed by Addison that a profound disturbance 

 of the nutrition, characterized by a bronze-like 

 discoloration of the skin and of the mucous 

 membranes of the mouth, extreme muscular 

 weakness, and profound anemia, was associated 

 with, if not dependent on, pathologic conditions 

 of the suprarenal glands. In the progress of the 

 disease the asthenia gradually increases, the heart 

 becomes weak, the pulse small, soft, and feeble, 

 indicating a general loss of tone of the muscular 

 and vascular apparatus. Death ensues from 

 paralysis of the respiratory muscles. The essen- 

 tial nature of the lesion which gives rise to these 

 symptoms has not been determined. 



fromvarious animals 



FIG. 189. SAGITTAL 

 SECTION OF THE 

 PITUITARY BODY 

 AND INFUNDI- 

 BULUM WITH 

 ADJOINING 

 PART OF THIRD 

 VENTRICLE. a. 

 Anterior lobe. 

 a'. A projection 

 from it toward 

 the front of the 

 infundibulum. 

 b. Posterior lobe 

 connected by a 

 stalk with the 

 infundibulum, i. 

 I.e. Lamina cin- 

 erea. o. Right 

 optic nerve, ch. 

 Section of optic 

 chiasm. r.o. Re- 

 cess of ventricle 

 above the chias- 



__ ma. cm. Corpus 



is invariably and in a short time followed by mammillare. 



T Vi ~ r i i (Schivalbe, from 



death, preceded by some of the symptoms char- Quain.} 

 acteristic of Addison's disease. Their develop- 

 mei t, however, is more acute. From the fact that animals so 

 pros nptly die after extirpation of these bodies, and the further fact 

 that the blood of such animals is toxic to the subjects of recent 

 extirpation, " but not to normal animals, the conclusion was drawn 

 that the function of the adrenal bodies is to remove from the blood 

 some toxic product of muscle metabolism. Its accumulation after 

 extirpation gives rise to death through auto-intoxication 1 ! " 

 Ttri'TBS suppo'ymun lMt the adrenals' might s'e'cTe'te' altd pour into 



