CAUSES OF DISEASE 19 



not the cause, has been effected. And the same is 

 true of lysis, it is the harbinger of the fact that the 

 infectious agents are being vanquished. In the matter 

 of termination, the rule is not always followed; accord- 

 ingly, we sometimes find pneumonia terminating by 

 lysis, and less often, typhoid fever by crisis. One 

 curious exception to the usual form that crisis takes, 

 i.e., reduction in temperature, occurs in Asiatic cholera. 

 Instead of the temperature falling, it rises from below 

 normal (sub-normal) to normal or above normal. The 

 characteristic feature of the crisis is thus reversed, a 

 thing which is associated with the other reversal that 

 takes place in the stationary period of cholera, i.e., a 

 sub-normal temperature. 



An infectious disease is due to the entrance 

 Local and and growth of infectious agents, and to the 

 General toxins (poisons) which the latter generate. 

 Infections. When infectious agents gain an entrance 

 into the body, they act in one of two ways, 

 namely : 



(i) Either they remain localized near their portal of 

 entry, or in some near or distant organ, during the 

 whole course of the disease; or, 



(2) they first establish a local lesion near their portal 

 of entry, or in some near or distant organ, and then, 

 from this as a focus, invade the whole body. 



The first instance is descriptive of what is called a 

 local injection, the second, of a general injection. In 



