290 BACTERIOLOGY. 



necrosis and caseation. This is particularly the case 

 when the infection is general — i.e., when the process is 

 of the acute miliary type. This pathological-anatom- 

 ical alteration is best seen in the tissues of the liver 

 and spleen of these animals, where the condition is most 

 pronounced. 



In general, the tubercular lesions can be divided into 

 those of strictly focal character — i.e., the miliary and 

 the conglomerate tubercles, and those which are more 

 diffuse in their nature. The latter lesions, although of 

 the same fundamental nature as the miliary tubercles, 

 are much greater in extent and not so sharply circum- 

 scribed. 



These latter lesions play a greater role in the pabliol- 

 ogy of the disease than do the miliary nodules, although 

 it is to the presence of the miliary nodules that the 

 disease owes its name. 



At autopsy the pathological manifestations of the dis- 

 ease are not infrequently seen to be confined to the seat 

 of inoculation and to the neighboring lymphatic glands. 

 These tissues will then present all the characteristics of the 

 tuberculous process in the stage of cheesy degeneration. 

 When the disease is general the degree of its extension 

 varies. Sometimes the small gray nodules — the miliary 

 tubercles — are only to be seen with the naked eye in the 

 tissues of the liver and spleen. Again, they may invade 

 the lungs, and commonly they are distributed over the 

 serous membranes of the intestines, the lungs, the heart, 

 and the brain. These simple gray nodules, as seen by 

 the naked eye, vary in size from that of a pin-point to 

 that of a hempseed, and, as a rule, are, in this stage, the 

 result of the fusion of two or more smaller miliary foci. 

 Though the two terms '* miliary" and '' conglomerate " . 



