THE BACILLUS OF GLANDERS. 317 



the tendency is toward an amalgamation of its histo- 

 logical constituents, and ultimately to necrosis with 

 caseation. The giant-cell formation common to tuber- 

 culosis is never seen in the glanders nodule. As 

 Baumgarten aptly puts it: ''The pathological mani- 

 festations of glanders, from the histological aspect, stand 

 midway between the acute 'purulent and the chronic in- 

 flammatory processes. ' ' ' Evidently these differences are 

 only to be explained by differences in the nature of the 

 causes that underlie the several affections. We have 

 studied the characteristics of bacillus tuberculosis ; we 

 shall now take up the bacillus of glanders and note the 

 striking differences between them. 



The Bacillus of Glanders (bacillus mallei). — In 

 1882 Loeffler and Schutz discovered in the diseased tis- 

 sues of animals suffering from glanders a bacillus that. 



Fig. 64. 



/ 



Bacillus of glanders {baciUus mcUleCi. 



when isolated in pure culture and inoculated into sus- 

 ceptible animals, possesses the property of reproducing 

 the disease with all its clinical and pathological mani- 

 'festations. It is therefore the cause of the disease. 



> For a further discussion of the pathology and path(^enesis of this disease 

 see Lehrbuch der ptathologischen Mykologie, by Baumgarten, 1890. See, also, 

 Wright : The Histological Lesions of Acute Glanders in Man. Journal of Ex- 

 perimental Medicine, vol. i. p. 577. 



