256 



THE PATHOGENIC FLAGELLATES 



99, p, 247, of a so-called indifferent form. Here, after elimination 

 of waste material from the fertilized cell (.4) the nucleus divides by 

 heteropolar mitosis to form a trophonucleus and a kinetonucleus. The 

 former consists of a central division centre (karyosome) and chromatin 

 which is arranged in eight groups; the latter, as described above, 

 divides to form the substance of the motile apparatus and the perma- 

 nent kinetonucleus, in which, again, Schaudinn finds eight chromatin 

 masses and a central division centre. The nucleus of the "female" 

 type of organism differs from that of the "indifferent" form in that a 

 large part of the "achromatic" portion of the nucleus is eliminated 

 before the first division of the copula. This eliminated part divides 



Fig. 101 



^ 



Trypanosoma noctuEP. (After Schaudinn.) A, elimination of the "male" part of the 

 nuclear material; fi, division of the so-called "male" part; C, heteropolar division of the 

 female nucleus and degeneration of the daughter nuclei of the "male" part; D, formation of 

 adult female cell. 



three times, forming eight minute nuclear masses, which finally 

 degenerate and disappear (Fig. 101), while the nucleus now divides 

 by heteropolar mitosis, as in the previous case. The nucleus of the 

 "male," on the other hand, eliminates the larger part of the nuclear 

 material which ordinarily goes to form the nucleus (trophonucleus) of 

 the cell, and this degenerates, while the smaller denser nucleus result- 

 ing from the first division now divides three times to form the nuclei 

 of the eight microgametes and a fourth time to form the tropho- 

 nucleus and kinetonucleus of these gametes. 



The nuclei are thus sexually differentiated, according to Schaudinn, 

 a statement which, if true, gives the first complete confirmation of 



